Faculty and Staff Directory » Auriel Willette

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Title: Assistant Professor
Department: Food Science and Human Nutrition

Office: 224d Mackay 2302 Osborn Dr., Ames, IA 50011
Phone number: +1 515 294 3110
Email: awillett@iastate.edu

View resume/vita


Research interests

  • Obesity, Metabolic Dysfunction, and Brain Outcomes using MRI, EEG, and PET
  • Cognitive and Affective Neuroscience
  • Neurological Disorders (Alzheimer’s disease)
  • Psychoneuroimmunology
  • Biomedical Big Data and Data Mining

Manuscripts in Review or Preparation

  1. Ambrosini YM, Borcherding D, Seo YJ, Segarra S, Glanemann B, Garden OA, Neuber S, Muller U, Dang V, Borts D, Atherly T, Willette AA, Jergens A, Mochel JP, Allenspach K. “Treatment with Hydrolyzed Diet Supplemented with Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in a Canine Model of Inflammatory Bowel Disease.” Science: Translational Medicine, in review.
  2. Ambrosini Y, Borcherding D, Seo YJ, Segarra S, Glanemann B, Garden OA, Neuber S, Müller U, Dang V, Borts D, Atherly T, Willette AA, Jergens A, Mochel JP, and Allenspach K. Treatment with Hydrolyzed Diet Supplemented with Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease. Frontiers in Veterinary Science, in review.
  3. Pappas C, Willette AA. CSF glucose tracks regional tau accumulation in a Braak stage specific manner via regional amyloid deposition, AD parental family history, and gender among cognitively impaired aged adults. Alzheimer’s & Dementia, in review.
  4. Klinedinst BS, Pappas C, Le ST, Wang Q, Meier N, Lim YL, Lanningham-Foster L, Morris MC, Willette AA. Associations of longitudinal lifestyle and socioeconomic factors related to DEXA-quantified body composition in middle to old age: a UK Biobank study. Diabetes, in revision.
  5. Le ST, Cerna J, Klinedinst BS, Frizell B, Willette AA. Mitochondrial Bioenergetics and Alzheimer’s Disease: Pyruvate Kinase and Associations with Neural and Cognitive Outcomes. Neurobiology of Aging, in revision.
  6. Willette AA, Pappas C, Klinedinst BS, Cerna J, Collazo-Martinez A, Dantzer R. Neuroinflammation, Depression and Alzheimer’s Disease: Insights from the Kynurenine Pathway. Biological Psychiatry, in review.
  7. Le ST, Klinedinst SB, Pappas C, Larsen B, Wang Q, Wang Y, Yu S, Wang L, Allenspach-Jorn K, Mochel JP, Bennett D, Willette AA. Age, diet, and genetic AD risk factors that track fluid intelligence changes over 6 Years. Journal of Alzheimer's Disease, in review.
  8. Klinedinst BS, Le ST, Pappas C, Meier N, Lim YL, Lanningham-Foster L, Morris MC, Bennett D, Willette AA. Red wine wins: contrasting alcohol types and longitudinal changes in cardiometabolic factors and cognitive performance. In preparation.
  9. Klinedinst BS, Wolf TD, Obhi HK, McLimans KE, Cerna J, Lim Y, Guinness AA, Villines J, Kanthasamy AG, Anantharam V, Willette AA. Insulin Resistance and Longitudinal Variation in Brain Atrophy and CSF biomarkers in Alzheimer’s Disease. In preparation.
  10. Hoscheidt SM, Nicholas CR, Willette AA, Ly M, Zetterberg H, Blennow K, Krause R, Gleason CE, Atwood CS, Carlsson CM, Asthana S, Johnson SC, Bendlin BB. Stressful life events are associated with insulin resistance, Alzheimer disease pathology, and hypometabolism in memory regions in APOE ε4 carriers. In preparation.
  11. Plagman AK, Pappas CA, Mochel J, Allenspach-Jorn K, Kanthasamy A, Anantharam V, Wang L, Willette AA. Fasting glucose, genetic risk for Alzheimer’s disease, and neural myelination patterns. In preparation.
  12. Rokad D, Harischandra DS, Lawana V, Sarkar S, Luo D, Jin H, Anantharam V, Kanthasamy A, Willette AA, Kanthasamy AG. Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking Machinery. In preparation.
  13. McLimans KE, Luo D, Webb JL, Izbicki P, Stegemoller E, Anantharam V, Kanthasamy A, Willette AA. Ameliorative effects of IGF-1 on dopamine uptake are dysregulated in Parkinson’s disease and rodent models. In preparation.

Publications since becoming Faculty (Mean IF=7.3)

  1. Klinedinst BS†, Pappas C†, Le S, McLimans K, Wolf T, Plagman A, Russell DW, Wang Q, Willette AA. Fluid intelligence, DEXA body composition measurements, and sex-specific immunologic mediation: a longitudinal UK Biobank cohort study. Brain, Behavior, and Immunity, in press. † = Shared first authorship.
  2. McLimans KE†, Clark BE†, Plagman A, Pappas C, Klinedinst B, Anatharam V; Kanthasamy A; Willette AA. Is CSF SOD1 a Biomarker of Tau but not Amyloid Induced Neurodegeneration in Alzheimer’s Disease? Antioxidants and Redox Signaling, 31(8), 572-578. † = Shared first authorship. Note: This paper was fast-tracked as an outstanding ‘News and Views’ article and accepted in its current form by 6 reviewers and the full editorial board.
  3. Ambrosini YM, Borcherding D, Seo YJ, Segarra S, Glanemann B, Garden OA, Neuber S, Müller U, Dang V, Borts D, Atherly T, Willette AA, Jergens AE, Mochel JP, Allenspach K. The Gut-Brain-Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Frontiers in Aging Neuroscience, in press.
  4. McLimans KE, Collazo-Martinez A, Mochel JP, Allenspach K, Willette AA. Serum Vitamin B12, and MTRR and Cubilin SNPs Predict Neural Outcomes across the AD Spectrum. European Journal of Nutrition, in press.
  5. Luo J, Padhi P, Jin H, Anantharam V, Zenitsky G, Wang Q, Willette AA, Kanthasamy A, Kanthasamy AG. Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson’s Disease. Journal of Neuroimmune Pharmacology, in press.
  6. Plagman A†, Hoscheidt SM†, McLimans KE, Klinedinst BS, Pappas C, Willette AA, for the Alzheimer’s Disease Neuroimaging Initiative. Cholecystokinin and Alzheimer’s Disease: A Biomarker of Metabolic Function, Neural Integrity, and Cognitive Performance. 2019. Neurobiology of Aging, 76, 201-207. † = Shared first authorship.
  7. Wolf T, Tsenkova V, Ryff C, Davidson R, Willette AA. Metabolic Dysfunction and Task-Induced Emotional Stress Reactivity: Neural and Cognitive Correlates in Middle-Aged Adults. 2018. Psychosomatic Medicine, 80(5), 452-459.
  8. Swanson A, Wolf W, Sitzmann A, Willette AA. The modulation of neuroinflammation in Alzheimer’s Disease. 2018. Behavioural Brain Research, 347, 49-56.
  9. McLimans KE, Webb BS, Anantharam V, Kanthasamy A, Willette AA, for the Alzheimer’s Disease Neuroimaging Initiative. Peripheral versus central index of metabolic dysfunction and associations with clinical and pathological outcomes in Alzheimer's disease. 2017. Journal of Alzheimer’s Disease 60(4), 1313-1324.
  10. Willette AA, Webb JL, Lutz MW, Bendlin BB, Wennberg AM, Oh JM, Roses A, Koscik RL, Hermann BP, Dowling NM, Asthana S, Johnson SC, for the Alzheimer’s Disease Neuroimaging Initiative. Family history modifies TOMM40 ‘523 memory effects in preclinical and AD cohorts. 2017. Alzheimer’s & Dementia 13(11), 1217-1225.
  11. McLimans L†, Willette AA†. Autotaxin and Alzheimer’s disease: a potential biomarker for brain insulin resistance. 2017. Journal of Alzheimer’s Disease 56(1), 403-413. † = Shared first authorship.
  12. Webb JL, Willette AA. Aging Modifies the Effect of GCH1 RS11158026 on DAT Uptake and Parkinson's Disease Clinical Severity. 2017. Neurobiology of Aging 50, 39-46.
  13. Senthilarumugamveiluk M, Anantharam V, Kanthasamy A, Willette AA, Ganapathysubramanian B, Nilakanta S. Big Data and Parkinson's disease: Exploration, Analyses and Data Challenges. 51st Hawaii International Conference on System Sciences. 2017.
  14. Swanson A†, Willette AA†, Alzheimer’s Disease Neuroimaging Initiative. Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. 2016. Brain, Behavior, and Immunity 58, 201-208. † = Shared first authorship.
  15. Webb JL, Wolf TD, Swanson AE, McLimans KE, Klinedinst B, Izbicki P, Willette AA. Quantitative Secondary Data Analysis: Utilizing Observational Studies for Integrative Neuroscience and Interdisciplinary Work. 2016. Organizational Research Methods 10.4135/9781473998100.  
  16. Willette AA, Bendlin BB. Confounders Regarding the Association of Insulin Resistance and Alzheimer Disease-Reply. 2016. JAMA Neurology 73(2), 240-241.
  17. Willette AA, Burns C, Bendlin BB. Insulin Resistance and APOE ε4. 2015. JAMA Neurology 72(12), 1536-1537.
  18. Willette AA†, Bendlin BB†, Birdsill AC, Johnson SC, Christian BT, La Rue A, Hermann BP, Koscik RL, Jonaitis EM, Sager MA, Asthana S. Insulin resistance predicts lower cerebral glucose utilization in late middle-age. 2015. JAMA Neurology 72(9), 1013-20. † = Shared first authorship.
  19. Willette AA. Does metabolic syndrome impact cognition and emotion in Alzheimer’s disease? 2016. European Journal of Neurology 23(2), 237-238.
  20. Willette AA, Modanlo N, Kapogiannis D, for the Alzheimer’s Disease Neuroimaging Initiative. Insulin resistance predicts medial temporal hypermetabolism in MCI conversion to Alzheimer’s disease. 2015. Diabetes 64(6), 1933-40.
  21. Willette AA, Johnson SC, Birdsill A, Sager M, Christian B, Baker L, Craft S, Oh J, Statz E, Hermann B, Jonaitis E, Koscik R, La Rue A, Asthana S, Bendlin B. Insulin resistance predicts brain amyloid deposition in late middle-aged adults. 2015. Alzheimer’s & Dementia 11(5), 504-510.e1.
  22. Willette AA, Kapogiannis D. Does the brain shrink as the waist expands? 2015. Ageing Research Reviews 20, 86-97.

Published works